DOIAbstract
Abstract: The recognition that apoptosis is regu-lated by an evolutionarily conserved set of polypep-tides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeosta-sis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2 might interact with some of the other biochemical signals implicated in cell death. J
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