Brains and Phantoms: An ICA Study of fMRI

Abstract. Biomedical signal processing is arguably the most success-ful application of independent component analysis (ICA) to real world data. For almost a decade, its use in connection with functional magnetic resonance imaging (fMRI) has allowed for data-driven analysis, partly re-moving the constraints for stringent experimental setups, which are often required by traditional methods based on the use of temporal references. Recent studies on the consistency of independent components have re-sulted in a series of tools enabling a more reliable use of ICA. In partic-ular, it is now rather easy to detect algorithmic overfitting and isolate subspaces of related activation. Yet, often the nature of the components may not be determined unambiguously. Focal fMRI signals, seemingly originating from within a subject’s brain and showing physiologically plausible temporal behavior, are typically considered relevant. This pa-per presents a study, which makes use of a standard homogeneous spher-ical phantom and shows evidence for artifacts caused by the measuring device or environment, with characteristics that could easily be misin-terpreted as physiological. Our results suggest that reliable analysis of fMRI data using ICA may be far more difficult than previously thought. At least, artificial behavior revealed by phantom analysis should be con-sidered when conclusions are drawn from real subject measurements.