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Inhibition is a cognitive ability that allows humans to respond flexibly rather than re-flexively to events. The purpose of this investigation is to elucidate the neural basis of inhibition in healthy humans. Combining magnetoencephalography and functional MRI, two unqiue brain imaging instruments, allows both key brain regions and the timing of neu-ronal processes involved with inhibition to be resolved. The study found strong evidence that the dorsolateral prefrontal cortex is an important component in programming inhibitory signals