Amyloid plaques appear early during Alzheimer’s disease (AD), and their development is intimately linked to activated astrocytes and microglia. Astrocytes are capable of accumulating substantial amounts of neuron-derived, amyloid (1–42) (A42)-positive material and other neuron-specific proteins as a consequence of their debris-clearing role in response to local neurodegeneration. Immunohistochemical analyses have suggested that astrocytes overburdened with these internalized materials can eventually undergo lysis, and radial dispersal of their cytoplasmic contents, including A42, can lead to the deposition of a persistent residue in the form of small, GFAP-rich, astrocytic amyloid plaques, first appearing in the molecular layer of the cereb...
The deposition of amyloid-beta (Aβ) plaques in the brain is one of the primary pathological characte...
Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alz...
Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly i...
Microglia and astrocytes contribute to Alzheimer’s disease (AD) etiology and may mediate early neuro...
Microglia and astrocytes contribute to Alzheimer’s disease (AD) etiology and may mediate early neuro...
The brain consists of various cell types, including neurons, astrocytes, and microglia. Neurons are ...
Alzheimer's disease is a neurodegenerative disease that affects the central nervous system and is ch...
Background: Despite the clear physical association between activated astrocytes and amyloid-beta (A ...
abstract: As Alzheimer’s disease (AD) increases in incidence, there is an increased investigation in...
Alzheimer’s disease (AD) is the most common form of dementia in our society. The disease is characte...
In Alzheimer's disease (AD), hallmark β-amyloid deposits are characterized by the presence of activa...
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Y...
Brain glial cells secrete several molecules that can modulate the survival of neurons after various ...
Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
The deposition of amyloid-beta (Aβ) plaques in the brain is one of the primary pathological characte...
Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alz...
Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly i...
Microglia and astrocytes contribute to Alzheimer’s disease (AD) etiology and may mediate early neuro...
Microglia and astrocytes contribute to Alzheimer’s disease (AD) etiology and may mediate early neuro...
The brain consists of various cell types, including neurons, astrocytes, and microglia. Neurons are ...
Alzheimer's disease is a neurodegenerative disease that affects the central nervous system and is ch...
Background: Despite the clear physical association between activated astrocytes and amyloid-beta (A ...
abstract: As Alzheimer’s disease (AD) increases in incidence, there is an increased investigation in...
Alzheimer’s disease (AD) is the most common form of dementia in our society. The disease is characte...
In Alzheimer's disease (AD), hallmark β-amyloid deposits are characterized by the presence of activa...
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Y...
Brain glial cells secrete several molecules that can modulate the survival of neurons after various ...
Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
The deposition of amyloid-beta (Aβ) plaques in the brain is one of the primary pathological characte...
Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alz...
Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly i...