of Interoperable Information Systems in Healthcare Organizations ANT ´ONIO GRILO∗,$, LU´IS VELEZ LAP ˜AO†,

A major challenge for business information systems (BIS) design and management within healthcare units is the need to accommodate the complexity and changeability in terms of their clinical protocols, technology, business and administrative processes. Interoperability is the response to these demands, but there are many ways to achieve an “interoperable” information system. In this chapter we address the requirements of a healthcare interop-erability framework to enhance enterprise architecture interoperability of healthcare orga-nizations, while maintaining the organization’s technical and operational environments, and installed technology. The healthcare interoperability framework is grounded on the combination of model driven architecture (MDA) and service-oriented architecture (SOA) technologies. The main argument in this chapter is to advocate the role of chief information officer (CIO) in dealing with challenges posed by the need to achieve BIS grounded on interoper-ability at the different layers, and in developing and executing an interoperability strategy, which must be aligned with the health organization’s business, administrative, and clinical processes. A case study of the Hospital de São Sebastião is described demonstrating the critical role of the CIO for the development of an interoperable platform