Shear stress biology of the endothelium

Abstract—The relationships between blood flow, mechanotrans-duction, and the localization of arterial lesions can now be ad-vanced by the incorporation of new technologies and the refine-ment of existing methods in imaging modalities, computational modeling, fluid dynamics, and high throughput genomics and proteomics. When combined with traditional cell and molecu-lar technologies, a powerful palette of investigative approaches is available to address shear stress biology of the endothelium at levels extending from nanoscale subcellular detailed mechanis-tic responses through to higher organizational levels of regional endothelial phenotypes and heterogeneous vascular beds. Keywords—Mechanotransduction, Biomechanics, High throug-hput analyses, Atherosclerosis, Vascular biolog