DOIAbstract
The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated. Introduction:Telomeres, telomerase, and cancer The ends of linear eukaryotic chromosomes contain specialized structures called telomeres (reviewed in McEachern et al., 2000; Collins, 2000). Human telomeres consist of tandem arrays of the hexameric sequence TTAGGG, with overall telom
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