Add to ORKG6-Arylpurines carrying a variety of substituents in the 9-position were prepared by Stille coupling between appropriately substituted 6-chloropurines and aryl(tributyl)tin, and the compounds were screened for antibacterial activity against Mycobacterium tuberculosis H37-Rv. The lowest minimum inhibitory concentration value, 0.78 íg/mL, was found for 9-benzyl-2-chloro-6-(2-furyl)purine. This compound exhibited relatively low cytotoxicity, and it was active against several singly drug-resistant strains of M. tuberculosis
To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series o...
1121-1127Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the ...
University: Charles University in Prague Faculty: Faculty of Pharmacy in Hradec Králové Department: ...
A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new comp...
Purine analogs modified in the five-membered ring have been synthesized and examined for antibacteri...
6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tu...
Purine analogs modified in the five-membered ring have been synthesized and examined for antibacteri...
6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tu...
Abstract. A series of 6-substituted purines were synthesized from commercially available 2-amino-6-c...
Preparation of 6-Aryl- and 6-Heteroarylpurines by [2+2+2]- Cyclotrimerizations Mgr. Pavel Turek Dept...
Dedicated to Dr. Alfred Bader for his generous support of chemical research and education. A novel a...
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as...
A seriesof twenty four acyclic unsaturated 2,6-substututed purines 5a-20b were synthesized. These co...
The emergence of drug-resistant strains in recent years has fueled the epidemic of tuberculosis. Thi...
A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring differ...
To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series o...
1121-1127Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the ...
University: Charles University in Prague Faculty: Faculty of Pharmacy in Hradec Králové Department: ...
A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new comp...
Purine analogs modified in the five-membered ring have been synthesized and examined for antibacteri...
6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tu...
Purine analogs modified in the five-membered ring have been synthesized and examined for antibacteri...
6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tu...
Abstract. A series of 6-substituted purines were synthesized from commercially available 2-amino-6-c...
Preparation of 6-Aryl- and 6-Heteroarylpurines by [2+2+2]- Cyclotrimerizations Mgr. Pavel Turek Dept...
Dedicated to Dr. Alfred Bader for his generous support of chemical research and education. A novel a...
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as...
A seriesof twenty four acyclic unsaturated 2,6-substututed purines 5a-20b were synthesized. These co...
The emergence of drug-resistant strains in recent years has fueled the epidemic of tuberculosis. Thi...
A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring differ...
To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series o...
1121-1127Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the ...
University: Charles University in Prague Faculty: Faculty of Pharmacy in Hradec Králové Department: ...