Infarction: Integration of Experimental and Computational Approaches

Progressive remodeling of the left ventricle (LV) following myocardial infarction (MI) involves spatiotemporal interactions among multiple cell types and the extracellular matrix environment. Despite the extensive experimental studies designed to elucidate the regulatory mechanisms, there is a growing recognition that the complexity of LV remodeling precludes the efficient identification of early diagnostic indicators after myocardial infarction. Currently, systemic approaches are needed to reduce this complexity. Previous studies in other systems demonstrate that establishing a multi-scale analytical model of LV remodeling response to MI will likely help in the development of prognostic therapies. In this review, we discuss the current approaches used for mathematical modeling of the LV, advantages and disadvantages of the approaches, and methods used to validate these models