1 BCR-ABL Hits at Mitosis; Implications for Chromosomal Instability, Aneuploidy and Therapeutic Strategy

1.1 Genomic and chromosomal instability in CML An unstable genome is a common hallmark of nearly all solid tumors and most of leukemias in contrast to normal, healthy cells which are able to maintein genome integrity (Negrini et al., 2010). Genomic instability could result from changes in chromosome structure an