Tel-Aviv University under the supervision of

I would like to thank my advisors Dr. Zohar Yakhini from Agilent Labs and the Technion and Prof. Benny Chor from Tel Aviv University for their guidance and support. I would especially like to thank Zohar for giving me the opportunity to work in this exciting field of computational biology. Specifically, for his dedicated attention, his inexhaustible patience, for the captivating numerous discussions on math, computer science, biology and their integration and for teaching me that making science is not limited only to the borders of the office/lab. Special thanks goes to my lab member – Israel Steinfeld, for his friendship, for being an important part of all the studies described in this thesis and for numerous fruitful discussions. I would like to thank Amir Ben-Dor from Agilent Labs for his collaboration on rank consistency scores, Hui Wang for her collaboration on cancer universal miRNAs, Eran Eden and Doron Lipson for their help with GOrilla, and our Italian collaborator – Diego Ardigo for our joint work on cardiovascular diseases. During my studies I found myself battling cancer, not only scientifically. I would like t