3 Recent Advances Concerning the Molecular Mechanism of Patent Ductus Arteriosus

The ductus arteriosus (DA), a fetal arterial shunt between the main pulmonary artery and the descending aorta, is a normal and essential fetal structure. Normally, the DA begins to close immediately after birth, but in some cases it remains patent after birth. Postnatal patent DA (PDA) is a major cause of morbidity and mortality in premature infants, leading to sever