CASE REPORTS

Monosomy 22 is an extremely rare chro-mosomal anomaly and only six patients have been described in the literature to date since the availability of banding tech-nique(1). A case of monosomy 22 mosai-cism is reported here because of its rarity. This is the fourth case reported so far of monosomy 22 mosaicism(2,4,5) and the first one amongst females. Case Report The proband, a VA year old female child, was the first issue of a healthy couple (Fig. 1). The second issue which is a male child, is absolutely normal. The age of the mother and father was 30 and 35 years, re-spectively. The marriage was a non-con-sanguineous one. A detailed pedigree anal-ysis revealed no chromosomal or genetic abnormality in the family. There was no previous history of miscarriage. The mother was not exposed to any drug or ionizing radiation antenatally. Intrauterine growth retardation was detected at 8 months of pregnancy. The patient was born at term by breech delivery. Birth weight was 1.6 kg. Poor weight gain and developmental failure were the chief complaints since neonatal period. However, dietary intake was ade