Immunosuppressive Effects of Mesenchymal Stem

Introduction. Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to sup-press allogenic T-cell response and modify maturation of antigen-presenting cells. Their role in the treatment of severe graft versus host disease has been reported. The underlying molecular mechanisms of immunosuppression are cur-rently being investigated. Histocompatibility locus antigen (HLA)-G is a nonclassical major histocompatibility com-plex class I antigen with strong immune-inhibitory properties