The developing synapse: Construction and modulation of synaptic structures and circuits

Synapse formation and stabilization in the vertebrate central nervous system is a dynamic process, requiring bi-directional communication between pre- and postsynaptic partners. Numerous mechanisms coordi-nate where and when synapses are made in the developing brain. This review discusses cellular and activity-dependent mechanisms that control the development of synaptic connectivity. The function of the nervous system critically relies on the establishment of precise synaptic connections between neurons and specific target cells (Fig. 1). During synaptogenesis, synapses form, mature, and stabilize and are also eliminated by a process that requires intimate communication between pre- and postsynaptic partners. Most of our under-standing of synapse formation and stabiliza