UNIVERSITY OF PISA

During the work on this Thesis, my life was characterized by some events that modified it. My marriage, the born of a child and the discover of a thyroid carcinoma weren’t loss many time to imagine the moment in which I would get to this part. Only now I realize this situation, looking back at this period of my life with pleasure and gratitude. Finally, this moment will come. The examiners will evaluate the results of this work, but I can certainly say that the process will be pleasant. So I am glad to complete it by remembering many wonderful people who have contributed to it in various ways. My firsts thanks goes to God, for its constant presence in my life, for guiding my choices and for the comfort in the difficult moments. Sincere thanks to my supervisor, Prof. Emo Chiellini, who gave me the opportunity to achieve this important objective. I also thank the reading committee members who kindly agreed to read my manuscript and to participate in this discussion. Special thanks to Maria Viola, Michela Bianchi and Maria Caccamo. Persons that help me in all situations