Address for correspondence: HELLP Syndrome – a Multisystemic Disorder

HELLP syndrome is a multisystemic disorder with an incidence of 0.17-0.85 % of all pregnancies. Its etiopatho-genesis is not completely understood. The most widely accepted hypotheses are: a change in the immune feto-mater-nal balance, platelet aggregation, endothelial dysfunction, arterial hypertension and an inborn error of the fatty acid oxidative metabolism. Hepatic involvement occurs by intravascular fibrin deposition and hypovolemia. Materno-fetal complications cause a 6.7-70 % perinatal mortality rate and a 1-24 % maternal mortality rate. The recognition of HELLP syndrome and the rapid initiation of therapy are required for the improvement of materno-fetal prognosis. Key words HELLP syndrome- preeclampsia- pregnancy- liver hematoma- diagnosis- therap