Republic

Abstract. Here we present a new image registration algorithm for the alignment of histological sections that combines the ideas of B-spline based elastic registration and consistent image registration, to allow si-multaneous registration of images in two directions (direct and inverse). In principle, deformations based on B-splines are not invertible. The con-sistency term overcomes this limitation and allows registration of two images in a completely symmetric way. This extension of the elastic reg-istration method simplifies the search for the optimum deformation and allows registering with no information about landmarks or deformation regularization. This approach can also be used as the first step to solve the problem of group-wise registration....