Final Topic Refinement Document Therapeutic Options for Obesity in the Medicare Population

KQ1. In patients who are obese and who would be eligible for Medicare, what is the comparative effectiveness of interventions that are intended to improve outcomes by reducing obesity? The outcomes of interest include: a. BMI b. Clinical outcomes ● Mortality ● Cancer mortality (any cause) ● Incidence of specific cancers: breast, colorectal cancer, endometrial cancer, esophageal adenocarcinoma, gall bladder cancer, and renal cell cancer ● Cardiovascular disease ● Non-alcoholic steatohepatitis (NASH) ● Degenerative joint disease (i.e., knee, hip) ● Respiratory disease (i.e., asthma, COPD) ● Sleep apnea c. Adverse effects of interventions ● Activity-related injury ● Adverse effects of medication ( diarrhea, leakage) ● Nutritional deficiencies (including eating disorders) ● Procedural complications (including death). KQ2. In patients who are obese and who would be eligible for Medicare, how well does treatment-induced reduction in BMI predict obesity-related outcomes? a. The outcomes of interest include the clinical outcomes ● Mortality ● Cancer mortality (any cause), ● Incidence of specific cancers: breast, colorectal cancer, endometrial cancer, esophageal adenocarcinoma, gall bladder cancer, and renal cell cancer ● Cardiovascular disease ● Non-alcoholic steatohepatitis (NASH) ● Degenerative joint disease (i.e., knee, hip) ● Respiratory disease (i.e., asthma, COPD