POSTERS PP-01 ELECTROCHEMICAL STUDY OF 3-(AZIDOMETHYLENE)DIHYDROFURAN-2-ONE

Organic azides are important compounds not only in organic synthesis but also in medicine as based molecule for preparation of drugs for HIV positive patients (e. g. azido-thymidin)1. From electrochemical point of view azide group is subject to reduction. In this study we discussed the reduction of 3-(azidomethylene) dihydrofurane-2-one (AZMDF), which occurs in two conformations: (E) form and (Z) form. These furanoid azides were prepared due to studying of reactivity of -tosyloxymethylenlactones2. Using linear sweep or cyclic voltammetry and elimination voltammetry with linear scan (EVLS) (ref.3–5) in connection with a mercury electrode, sig-nals of (E) and (Z) forms of AZMDF were clearly distin-guished. In addition, we optimized experimental conditions to enhance sensitivity of determination of target molecules. The highest reduction signals of both isomers were measured i