MAGNETIC NANOPARTICLES IMPACT ON TUMORAL CELLS IN THE TREATMENT BY MAGNETIC FLUID HYPERTHERMIA

The heat-induced cell death with magnetic nanoparticles (MNPs) generates numerous cellular changes, leading to morphological changes, cell detachment, and death. Cellular alterations include, changes in the membrane, nuclear and cytoskeletal structures, cellular metabolism, macromolecular synthesis etc. In this work the purpose is to explain the main mechanisms of magnetic fluid hyperthermia (MFH), more precisely the heating mechanisms of MNPs and the effects of this heating on extracelullar and intracellular environments