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remodeling, and cell migration [1]. For example, larval tissues such as the gut, salivary gland [2], silk gland [3], and larval-of these two hormones defines the outcome of each develop-mental transition [5]. To date, a series of genes related to insect development and metamorphosis has been cloned and investigated. Extensive Genomics 90 (2007) 3specific muscles undergo programmed cell death and subse-Keywords: Bombyx mori; cDNA; gene expression; GLGI; SAGE; microarray; silkworm Insects are the most widely distributed and successful animal class in the world. Rapid propagation and complicated meta-morphosis are the pivotal reasons for this success. Because of metamorphosis, insects can survive either high-heat or below-freezing environmental conditions. During molting and meta-morphosis, diverse morphological, physiological, biochemical, and molecular events result in distinct developmental changes such as cellular proliferation, programmed cell death, tissu