Original Article Waiting to win: elevated striatal and

orbitofrontal cortical activity during reward anticipation in euthymic bipolar disorder adults Bipolar disorder is a severe and recurrent illness involving significant impairment, including erratic work performance, high rates of divorce and suicide, and high rates of alcohol and substance abuse (1, 2). Yet, bipolar disorder is often diag-nosed late in illness course, or misdiagnosed as other illnesses such as unipolar depression (3). Examination of underlying pathophysiologica