Add to ORKGAmino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework. We find that the evo-lution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.
Proteins in the same species evolve at different rates so the systems evolutionary genomics field st...
Evolutionary rate and gene age are interrelated when the age of a gene is assessed by the taxonomic ...
BACKGROUND: Since thermodynamic stability is a global property of proteins that has to be conserved ...
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and ac...
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and ac...
The rate of protein evolution varies more than 1000-fold and, for the past 30 years, it was thought ...
The rate of protein evolution varies more than 1000-fold and, for the past 30 years, it was thought ...
1\. Contents and Introduction 1 2\. Preliminaries 9 3\. Family specific rates of protein evol...
Since the modern evolutionary synthesis was first proposed early in the twentieth century, attention...
The consistent observation across all kingdoms of life that highly abundant proteins evolve slowly d...
A fundamental question for evolutionary biology is why different proteins evolve at dramatically dif...
Adaptive mutations play an important role in molecular evolution. However, the frequency and nature ...
SummaryThe consistent observation across all kingdoms of life that highly abundant proteins evolve s...
We develop an approximate maximum likelihood method to estimate flanking nucleotide context-dependen...
The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the e...
Proteins in the same species evolve at different rates so the systems evolutionary genomics field st...
Evolutionary rate and gene age are interrelated when the age of a gene is assessed by the taxonomic ...
BACKGROUND: Since thermodynamic stability is a global property of proteins that has to be conserved ...
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and ac...
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and ac...
The rate of protein evolution varies more than 1000-fold and, for the past 30 years, it was thought ...
The rate of protein evolution varies more than 1000-fold and, for the past 30 years, it was thought ...
1\. Contents and Introduction 1 2\. Preliminaries 9 3\. Family specific rates of protein evol...
Since the modern evolutionary synthesis was first proposed early in the twentieth century, attention...
The consistent observation across all kingdoms of life that highly abundant proteins evolve slowly d...
A fundamental question for evolutionary biology is why different proteins evolve at dramatically dif...
Adaptive mutations play an important role in molecular evolution. However, the frequency and nature ...
SummaryThe consistent observation across all kingdoms of life that highly abundant proteins evolve s...
We develop an approximate maximum likelihood method to estimate flanking nucleotide context-dependen...
The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the e...
Proteins in the same species evolve at different rates so the systems evolutionary genomics field st...
Evolutionary rate and gene age are interrelated when the age of a gene is assessed by the taxonomic ...
BACKGROUND: Since thermodynamic stability is a global property of proteins that has to be conserved ...