white blood cells for the imaging of infection

&p.1:Abstract. Technetium-99m labelled antigranulocyte an-tibodies are ready to use and are sensitive and specific in the diagnosis of infectious diseases. 99mTc-SSEA anti-granulocyte antibodies have a very high affinity constant (Kd 10–12 M) for human neutrophils (PMNs), and excel-lent imaging qualities with high target/background ra-tios. The aim of this study was to compare the diagnostic accuracy of the 99mTc-anti-SSEA-1 monoclonal antibody (Mab) with that of 99mTc-hexamethylpropylene amine oxime (HMPAO)-labelled white blood cells (WBCs). To this end, 17 patients with 23 proven infectious foci were examined with 555 MBq 99mTc-anti-SSEA-1 MAb and with 370 MBq 99mTc-HMPAO labelled autologous leu-cocytes within a period of 7 days. All the infections were confirmed by culture, biopsy, surgery and follow