Comparison of the Intraocular Pressure Lowering Effect of Latanoprost and Carteolol- pilocarpine Combination in Newly Diagnosed Glaucoma

To evaluate the comparative efficacy of latanoprost monotherapy versus combined carteolol and pilocarpine therapy in patients with newly diagnosed glaucoma. Methods: Masked randomized prospective trial. This study included 51 patients (64 eyes) with newly diagnosed glaucoma or ocular hypertension. The cases were randomly divided into two treatment groups for administration of latanoprost 0.005 % once daily, or of car-teolol 2 % twice daily and pilocarpine 2 % twice daily. Mean diurnal intraocular pressure (IOP) was measured at baseline, week 2, week 4, and month 3 after the beginning of treat-ment. Changes in mean IOP from baseline to the 3-month visit were determined by an analy-sis of variance. Results: Mean diurnal IOP values were 25.